DIY Prog: Attempt 2

Recipe

I made several changes for this second attempt:

I halved the volume. My experience with 2ml pessaries left me annoyed—I felt like I was leaking way more than I'd like, including active ingredient. It made a mess and was wasteful. So I found some 1ml moulds.
I doubled the active ingredient. I wanted to see if I could get my full prescribed dose to dissolve in the smaller volume. Although I like taking 100 mg in the a.m. and 100 in the p.m., I found the effect distracting—progesterone has a vasodilatory effect and attracts bloodflow—and it is a little inconvenient, so I cut back to one a day.
- As a result, each 1ml bear is ~23% progesterone and ~77% base. Despite appearing to be a large relative volume of micronized powder, it appeared to dissolve well.
I used Supposi-Plex V65 for the excipient. I wanted to see how differently it handled from the stuff that is more readily obtainable (this is generally sold to pharmacies). It's a waxy compound formulated for vaginal insertion. From the technical data sheet:

a manufactured mixture of triglycerides from vegetable origins, ethoxylated cetylstearyl alcohol, and cera alba (beeswax).

Yes (my subjective experience only). It took longer to feel active effects, which lasted longer, than attempt 1.

Fairly rigid at room temperature—less melty than the coco butter + coconut oil. These harden at room temperature, though I keep them in the fridge.

Adorable.

Feels a little like inserting a lego
- These are small enough that it isn't really uncomfortable, exactly. But they take a little longer to soften than attempt 1, so there was a more noticable sensation of something being in there for a few minutes.